Detailed information of TA system TA291702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4948221..4949902
• Replicon: chromosome
• Accession: NZ_LR890648
• Organism: Klebsiella pneumoniae isolate INF266-sc-2280182

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: JMW87_RS24160
• Protein ID: WP_004146663.1
• Coordinates: 4948221..4949138 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMW87_RS24165
• Protein ID: WP_004177809.1
• Coordinates: 4949144..4949902 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW87_RS24140	4943527..4945047	+	1521	WP_032738364.1	sugar ABC transporter ATP-binding protein	-
JMW87_RS24145	4945044..4946042	+	999	WP_012737175.1	ribose ABC transporter permease	-
JMW87_RS24150	4946073..4947014	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW87_RS24155	4947089..4948096	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
JMW87_RS24160	4948221..4949138	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW87_RS24165	4949144..4949902	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW87_RS24170	4949988..4950716	-	729	WP_004177810.1	response regulator transcription factor	-
JMW87_RS24175	4950989..4953136	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW87_RS24180	4953366..4954052	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T291702 WP_004146663.1 NZ_LR890648:c4949138-4948221 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT291702 WP_004177809.1 NZ_LR890648:c4949902-4949144 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05