Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4652389..4653199 Replicon chromosome
Accession NZ_LR890648
Organism Klebsiella pneumoniae isolate INF266-sc-2280182

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag JMW87_RS22805 Protein ID WP_014908042.1
Coordinates 4652389..4652922 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag JMW87_RS22810 Protein ID WP_023343051.1
Coordinates 4652933..4653199 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW87_RS22800 4651220..4652341 + 1122 WP_012737335.1 cupin domain-containing protein -
JMW87_RS22805 4652389..4652922 - 534 WP_014908042.1 GNAT family N-acetyltransferase Toxin
JMW87_RS22810 4652933..4653199 - 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
JMW87_RS22815 4653302..4654735 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
JMW87_RS22820 4654725..4655408 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMW87_RS22825 4655581..4656966 + 1386 WP_024623207.1 efflux transporter outer membrane subunit -
JMW87_RS22830 4656984..4657328 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T291700 WP_014908042.1 NZ_LR890648:c4652922-4652389 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT291700 WP_023343051.1 NZ_LR890648:c4653199-4652933 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References