Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2589186..2590774 | Replicon | chromosome |
Accession | NZ_LR890648 | ||
Organism | Klebsiella pneumoniae isolate INF266-sc-2280182 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A485W5A2 |
Locus tag | JMW87_RS12575 | Protein ID | WP_023342812.1 |
Coordinates | 2589186..2590508 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JMW87_RS12580 | Protein ID | WP_024622638.1 |
Coordinates | 2590508..2590774 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW87_RS12560 | 2584242..2586743 | + | 2502 | WP_023342811.1 | fimbrial biogenesis outer membrane usher protein | - |
JMW87_RS12565 | 2586731..2587735 | + | 1005 | WP_004224758.1 | type 1 fimbrial protein | - |
JMW87_RS12570 | 2587877..2589169 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
JMW87_RS12575 | 2589186..2590508 | - | 1323 | WP_023342812.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMW87_RS12580 | 2590508..2590774 | - | 267 | WP_024622638.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JMW87_RS12585 | 2591039..2591365 | - | 327 | WP_004184023.1 | hydroxyisourate hydrolase | - |
JMW87_RS12590 | 2591362..2591862 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
JMW87_RS12595 | 2591840..2593219 | - | 1380 | WP_004184021.1 | purine permease | - |
JMW87_RS12600 | 2593565..2594719 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
JMW87_RS12605 | 2594700..2595623 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | mgtC / iroE | 2391575..2624432 | 232857 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.46 Da Isoelectric Point: 7.5358
>T291697 WP_023342812.1 NZ_LR890648:c2590508-2589186 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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