Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4655894..4656410 Replicon chromosome
Accession NZ_LR890643
Organism Klebsiella pneumoniae isolate INF346-sc-2280166

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag JMW14_RS22845 Protein ID WP_004192395.1
Coordinates 4655894..4656178 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag JMW14_RS22850 Protein ID WP_004192397.1
Coordinates 4656168..4656410 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW14_RS22820 4651311..4651619 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
JMW14_RS22825 4651704..4651877 + 174 WP_002886906.1 hypothetical protein -
JMW14_RS22830 4651880..4652623 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW14_RS22835 4652980..4655118 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW14_RS22840 4655426..4655890 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW14_RS22845 4655894..4656178 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW14_RS22850 4656168..4656410 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW14_RS22855 4656488..4658398 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMW14_RS22860 4658421..4659575 - 1155 WP_004178372.1 lactonase family protein -
JMW14_RS22865 4659642..4660382 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T291686 WP_004192395.1 NZ_LR890643:c4656178-4655894 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT291686 WP_004192397.1 NZ_LR890643:c4656410-4656168 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References