Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4574710..4575387 Replicon chromosome
Accession NZ_LR890643
Organism Klebsiella pneumoniae isolate INF346-sc-2280166

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JMW14_RS22485 Protein ID WP_069303595.1
Coordinates 4574710..4575030 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JMW14_RS22490 Protein ID WP_110216231.1
Coordinates 4575064..4575387 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW14_RS22460 4569889..4570773 + 885 WP_004192285.1 RES domain-containing protein -
JMW14_RS22465 4570972..4571160 - 189 Protein_4400 transposase -
JMW14_RS22470 4571177..4572288 - 1112 Protein_4401 IS3 family transposase -
JMW14_RS22475 4572682..4573689 - 1008 WP_017880110.1 restriction endonuclease -
JMW14_RS22480 4573766..4574596 - 831 WP_110216229.1 DUF4942 domain-containing protein -
JMW14_RS22485 4574710..4575030 - 321 WP_069303595.1 TA system toxin CbtA family protein Toxin
JMW14_RS22490 4575064..4575387 - 324 WP_110216231.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW14_RS22495 4575400..4575870 - 471 WP_069303593.1 DNA repair protein RadC -
JMW14_RS22500 4575941..4576762 - 822 WP_069303592.1 DUF945 domain-containing protein -
JMW14_RS22505 4576861..4577073 - 213 WP_110184539.1 hypothetical protein -
JMW14_RS22510 4577155..4577514 - 360 WP_110184538.1 hypothetical protein -
JMW14_RS22515 4577601..4578065 - 465 WP_069303590.1 hypothetical protein -
JMW14_RS22520 4578120..4578797 - 678 WP_069303589.1 WYL domain-containing protein -
JMW14_RS22525 4578857..4579585 - 729 WP_069303588.1 DUF3944 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4563051..4599261 36210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12077.65 Da        Isoelectric Point: 5.0356

>T291685 WP_069303595.1 NZ_LR890643:c4575030-4574710 [Klebsiella pneumoniae]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFQDDEAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12031.59 Da        Isoelectric Point: 5.4947

>AT291685 WP_110216231.1 NZ_LR890643:c4575387-4575064 [Klebsiella pneumoniae]
MPFTLSHGWGIQSDITQRFGARLVQEGNRLHYLADRASLTGSFSPEQLQSLENAFPLFIEQLGNMLRSGELNPQQQHQMT
IQLTGLTCIADTLSSWGYVYLTVYPAQ

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References