Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2562344..2563932 Replicon chromosome
Accession NZ_LR890643
Organism Klebsiella pneumoniae isolate INF346-sc-2280166

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag JMW14_RS12565 Protein ID WP_004190166.1
Coordinates 2562344..2563666 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW14_RS12570 Protein ID WP_002904790.1
Coordinates 2563666..2563932 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW14_RS12550 2557400..2559901 + 2502 WP_004190161.1 fimbrial biogenesis outer membrane usher protein -
JMW14_RS12555 2559889..2560893 + 1005 WP_004190163.1 type 1 fimbrial protein -
JMW14_RS12560 2561035..2562327 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW14_RS12565 2562344..2563666 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW14_RS12570 2563666..2563932 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW14_RS12575 2564197..2564523 - 327 WP_004143476.1 hydroxyisourate hydrolase -
JMW14_RS12580 2564520..2565020 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW14_RS12585 2564998..2566377 - 1380 WP_004184021.1 purine permease -
JMW14_RS12590 2566723..2567877 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW14_RS12595 2567858..2568781 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T291682 WP_004190166.1 NZ_LR890643:c2563666-2562344 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291682 WP_002904790.1 NZ_LR890643:c2563932-2563666 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References