Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2223813..2224711 Replicon
Accession NC_020559
Organism Mycobacterium tuberculosis str. Erdman = ATCC 35801

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag ERDMAN_RS10430 Protein ID WP_003410001.1
Coordinates 2223813..2224373 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag ERDMAN_RS10435 Protein ID WP_003410003.1
Coordinates 2224370..2224711 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERDMAN_RS10400 2218982..2219635 - 654 WP_003409976.1 cutinase Cfp21 -
ERDMAN_RS10405 2219750..2219980 + 231 WP_003409980.1 DUF167 domain-containing protein -
ERDMAN_RS10410 2220065..2220976 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
ERDMAN_RS10415 2221085..2221684 + 600 WP_003409989.1 L-lysine exporter -
ERDMAN_RS10420 2222100..2222528 + 429 WP_003409992.1 cellulose-binding protein -
ERDMAN_RS10425 2222754..2223293 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
ERDMAN_RS10430 2223813..2224373 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
ERDMAN_RS10435 2224370..2224711 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
ERDMAN_RS10440 2224797..2225054 + 258 WP_003410006.1 hypothetical protein -
ERDMAN_RS10445 2224955..2225290 - 336 WP_003410009.1 dehydrogenase -
ERDMAN_RS10450 2225379..2225723 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
ERDMAN_RS10455 2225717..2225965 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
ERDMAN_RS10460 2226065..2228380 - 2316 WP_003899120.1 cation transporter ATPase CptG -
ERDMAN_RS10465 2228377..2228649 - 273 WP_003410017.1 DUF1490 family protein -
ERDMAN_RS10470 2228702..2229058 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T29167 WP_003410001.1 NC_020559:c2224373-2223813 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T29167 NC_020559:c2224373-2223813 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT29167 WP_003410003.1 NC_020559:c2224711-2224370 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT29167 NC_020559:c2224711-2224370 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References