Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4597430..4598087 Replicon chromosome
Accession NZ_LR890640
Organism Klebsiella pneumoniae isolate INF344-sc-2280162

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW76_RS22385 Protein ID WP_002916310.1
Coordinates 4597677..4598087 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW76_RS22380 Protein ID WP_002916312.1
Coordinates 4597430..4597696 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW76_RS22355 4592638..4594071 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMW76_RS22360 4594190..4594918 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW76_RS22365 4594968..4595279 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JMW76_RS22370 4595443..4596102 + 660 WP_002916317.1 hemolysin III family protein -
JMW76_RS22375 4596201..4597184 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMW76_RS22380 4597430..4597696 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW76_RS22385 4597677..4598087 + 411 WP_002916310.1 protein YgfX Toxin
JMW76_RS22390 4598094..4598615 - 522 WP_004144730.1 flavodoxin FldB -
JMW76_RS22395 4598716..4599612 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW76_RS22400 4599635..4600348 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW76_RS22405 4600354..4602087 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291668 WP_002916310.1 NZ_LR890640:4597677-4598087 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291668 WP_002916312.1 NZ_LR890640:4597430-4597696 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References