Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2533035..2533654 | Replicon | chromosome |
Accession | NZ_LR890640 | ||
Organism | Klebsiella pneumoniae isolate INF344-sc-2280162 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | JMW76_RS12385 | Protein ID | WP_002892050.1 |
Coordinates | 2533436..2533654 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | JMW76_RS12380 | Protein ID | WP_002892066.1 |
Coordinates | 2533035..2533409 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW76_RS12370 | 2528187..2529380 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
JMW76_RS12375 | 2529403..2532549 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
JMW76_RS12380 | 2533035..2533409 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
JMW76_RS12385 | 2533436..2533654 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
JMW76_RS12390 | 2533817..2534383 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
JMW76_RS12395 | 2534355..2534495 | - | 141 | WP_201524398.1 | hypothetical protein | - |
JMW76_RS12400 | 2534516..2534986 | + | 471 | WP_104159009.1 | YlaC family protein | - |
JMW76_RS12405 | 2534961..2536412 | - | 1452 | WP_201524399.1 | PLP-dependent aminotransferase family protein | - |
JMW76_RS12410 | 2536513..2537211 | + | 699 | WP_094310543.1 | GNAT family N-acetyltransferase | - |
JMW76_RS12415 | 2537208..2537348 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
JMW76_RS12420 | 2537348..2537611 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
JMW76_RS12425 | 2537753..2538349 | + | 597 | Protein_2439 | GNAT family N-acetyltransferase | - |
JMW76_RS12430 | 2538346..2538486 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T291661 WP_002892050.1 NZ_LR890640:2533436-2533654 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT291661 WP_002892066.1 NZ_LR890640:2533035-2533409 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |