Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1278296..1279884 Replicon chromosome
Accession NZ_LR890640
Organism Klebsiella pneumoniae isolate INF344-sc-2280162

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag JMW76_RS06310 Protein ID WP_002904792.1
Coordinates 1278296..1279618 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW76_RS06315 Protein ID WP_002904790.1
Coordinates 1279618..1279884 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW76_RS06295 1273352..1275853 + 2502 WP_004184030.1 fimbrial biogenesis outer membrane usher protein -
JMW76_RS06300 1275841..1276845 + 1005 WP_009308876.1 type 1 fimbrial protein -
JMW76_RS06305 1276987..1278279 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW76_RS06310 1278296..1279618 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW76_RS06315 1279618..1279884 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW76_RS06320 1280150..1280476 - 327 WP_201524377.1 hydroxyisourate hydrolase -
JMW76_RS06325 1280473..1280973 - 501 WP_064114890.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW76_RS06330 1280951..1282330 - 1380 WP_104158932.1 purine permease -
JMW76_RS06335 1282676..1283830 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW76_RS06340 1283811..1284734 - 924 WP_104159103.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 1083937..1314720 230783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T291659 WP_002904792.1 NZ_LR890640:c1279618-1278296 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291659 WP_002904790.1 NZ_LR890640:c1279884-1279618 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References