Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4217115..4217631 Replicon chromosome
Accession NZ_LR890632
Organism Klebsiella pneumoniae isolate INF299-sc-2280084

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMX65_RS20920 Protein ID WP_040216106.1
Coordinates 4217347..4217631 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMX65_RS20915 Protein ID WP_064162488.1
Coordinates 4217115..4217357 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX65_RS20900 4213143..4213883 + 741 WP_002886899.1 KDGP aldolase family protein -
JMX65_RS20905 4213950..4215104 + 1155 WP_064162489.1 lactonase family protein -
JMX65_RS20910 4215127..4217037 + 1911 WP_023325426.1 BglG family transcription antiterminator -
JMX65_RS20915 4217115..4217357 + 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX65_RS20920 4217347..4217631 + 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX65_RS20925 4217635..4218099 - 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX65_RS20930 4218407..4220545 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX65_RS20935 4220902..4221645 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX65_RS20940 4221648..4221821 - 174 WP_032425422.1 hypothetical protein -
JMX65_RS20945 4221906..4222214 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T291643 WP_040216106.1 NZ_LR890632:4217347-4217631 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT291643 WP_064162488.1 NZ_LR890632:4217115-4217357 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References