Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3702254..3702879 Replicon chromosome
Accession NZ_LR890632
Organism Klebsiella pneumoniae isolate INF299-sc-2280084

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMX65_RS18410 Protein ID WP_002882817.1
Coordinates 3702496..3702879 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX65_RS18405 Protein ID WP_004150355.1
Coordinates 3702254..3702496 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX65_RS18380 3698245..3698844 + 600 WP_004151865.1 glucose-1-phosphatase -
JMX65_RS18385 3698838..3699698 + 861 WP_004146232.1 virulence factor BrkB family protein -
JMX65_RS18390 3699695..3700132 + 438 WP_064162494.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX65_RS18395 3700177..3701118 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX65_RS18400 3701132..3702049 - 918 WP_004181612.1 alpha/beta hydrolase -
JMX65_RS18405 3702254..3702496 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX65_RS18410 3702496..3702879 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX65_RS18415 3703053..3703982 - 930 WP_064162495.1 formate dehydrogenase accessory protein FdhE -
JMX65_RS18420 3703979..3704614 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX65_RS18425 3704611..3705513 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T291642 WP_002882817.1 NZ_LR890632:3702496-3702879 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291642 WP_004150355.1 NZ_LR890632:3702254-3702496 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References