Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 218617..219356 Replicon plasmid 2
Accession NZ_LR890625
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMX20_RS26230 Protein ID WP_021312536.1
Coordinates 218617..219102 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX20_RS26235 Protein ID WP_003026799.1
Coordinates 219090..219356 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS26200 213761..214198 - 438 WP_201530453.1 hypothetical protein -
JMX20_RS26205 214294..215361 - 1068 WP_048291875.1 hypothetical protein -
JMX20_RS26210 215430..215726 - 297 WP_201530454.1 hydrogenase expression/formation protein HypD -
JMX20_RS26215 215960..216337 + 378 WP_032719541.1 hypothetical protein -
JMX20_RS26220 216534..217508 - 975 WP_048291873.1 hypothetical protein -
JMX20_RS26225 218113..218274 - 162 WP_004118124.1 type I toxin-antitoxin system Hok family toxin -
JMX20_RS26230 218617..219102 - 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
JMX20_RS26235 219090..219356 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX20_RS26240 219489..219917 - 429 WP_004901287.1 GFA family protein -
JMX20_RS26245 220118..220264 - 147 WP_159193595.1 IS3 family transposase -
JMX20_RS26250 220286..221406 + 1121 WP_101837575.1 IS3 family transposase -
JMX20_RS26255 221433..222248 - 816 WP_077268817.1 IS3 family transposase -
JMX20_RS26260 222203..222712 - 510 WP_004901294.1 IS3 family transposase -
JMX20_RS26265 223408..223668 + 261 WP_048291871.1 hypothetical protein -
JMX20_RS26270 223779..224249 - 471 WP_004144067.1 RES family NAD+ phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..233683 233683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T291633 WP_021312536.1 NZ_LR890625:c219102-218617 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291633 WP_003026799.1 NZ_LR890625:c219356-219090 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References