Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 174928..175571 Replicon plasmid 2
Accession NZ_LR890625
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMX20_RS26005 Protein ID WP_023345587.1
Coordinates 174928..175344 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JMX20_RS26010 Protein ID WP_023345588.1
Coordinates 175341..175571 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS25990 170525..171160 + 636 WP_023345584.1 DUF1349 domain-containing protein -
JMX20_RS25995 171549..173423 + 1875 WP_048291888.1 beta-glucoside-specific PTS transporter subunit IIABC -
JMX20_RS26000 173433..174836 + 1404 WP_023345586.1 glycoside hydrolase family 1 protein -
JMX20_RS26005 174928..175344 - 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX20_RS26010 175341..175571 - 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX20_RS26015 175989..176831 - 843 WP_048291887.1 nitroreductase family protein -
JMX20_RS26020 176899..177483 - 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
JMX20_RS26025 177595..177990 - 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
JMX20_RS26030 178093..178938 + 846 WP_023345593.1 SDR family oxidoreductase -
JMX20_RS26035 179051..179479 + 429 WP_023345594.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..233683 233683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T291631 WP_023345587.1 NZ_LR890625:c175344-174928 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT291631 WP_023345588.1 NZ_LR890625:c175571-175341 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References