Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 160412..161216 Replicon plasmid 2
Accession NZ_LR890625
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag JMX20_RS25940 Protein ID WP_072198182.1
Coordinates 160689..161216 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag JMX20_RS25935 Protein ID WP_048264996.1
Coordinates 160412..160681 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS25925 157065..158312 - 1248 WP_048264960.1 nucleotidyltransferase -
JMX20_RS25930 158309..159484 - 1176 WP_077258344.1 SAVED domain-containing protein -
JMX20_RS25935 160412..160681 + 270 WP_048264996.1 DUF1778 domain-containing protein Antitoxin
JMX20_RS25940 160689..161216 + 528 WP_072198182.1 GNAT family N-acetyltransferase Toxin
JMX20_RS25945 161300..161608 + 309 WP_064167953.1 hypothetical protein -
JMX20_RS25950 161659..162356 + 698 Protein_146 IS1 family transposase -
JMX20_RS25955 162668..163570 - 903 WP_048265000.1 LysR family transcriptional regulator -
JMX20_RS25960 163668..164276 + 609 WP_023345578.1 short chain dehydrogenase -
JMX20_RS25965 164395..165576 - 1182 WP_023345579.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..233683 233683
- flank IS/Tn - - 161853..162356 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20078.04 Da        Isoelectric Point: 5.7389

>T291630 WP_072198182.1 NZ_LR890625:160689-161216 [Klebsiella pneumoniae]
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE

Download         Length: 528 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.65 Da        Isoelectric Point: 10.1733

>AT291630 WP_048264996.1 NZ_LR890625:160412-160681 [Klebsiella pneumoniae]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References