Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 20483..21234 Replicon plasmid 2
Accession NZ_LR890625
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name ataT Uniprot ID A0A6P1V716
Locus tag JMX20_RS25345 Protein ID WP_048978473.1
Coordinates 20752..21234 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6P1V8A4
Locus tag JMX20_RS25340 Protein ID WP_048978474.1
Coordinates 20483..20761 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS25325 17617..18075 + 459 WP_173675456.1 hypothetical protein -
JMX20_RS25330 18318..18632 - 315 WP_201530455.1 hypothetical protein -
JMX20_RS25335 19639..20175 - 537 WP_048978475.1 hypothetical protein -
JMX20_RS25340 20483..20761 + 279 WP_048978474.1 DUF1778 domain-containing protein Antitoxin
JMX20_RS25345 20752..21234 + 483 WP_048978473.1 GNAT family N-acetyltransferase Toxin
JMX20_RS25350 21272..21676 + 405 WP_004210282.1 DUF2251 domain-containing protein -
JMX20_RS25355 22440..23912 + 1473 WP_077268816.1 conjugative transfer system coupling protein TraD -
JMX20_RS25360 23905..24663 + 759 WP_063445087.1 TIGR03747 family integrating conjugative element membrane protein -
JMX20_RS25365 24748..25434 - 687 WP_048330700.1 hypothetical protein -
JMX20_RS25370 25626..25973 + 348 WP_048330699.1 hypothetical protein -
JMX20_RS25375 25973..26215 + 243 WP_003029734.1 TIGR03758 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..233683 233683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17763.69 Da        Isoelectric Point: 9.4946

>T291629 WP_048978473.1 NZ_LR890625:20752-21234 [Klebsiella pneumoniae]
MGLRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10694.21 Da        Isoelectric Point: 4.5038

>AT291629 WP_048978474.1 NZ_LR890625:20483-20761 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWD

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V716

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8A4

References