Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5159982..5160607 Replicon chromosome
Accession NZ_LR890624
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMX20_RS24855 Protein ID WP_062921072.1
Coordinates 5159982..5160365 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX20_RS24860 Protein ID WP_004150355.1
Coordinates 5160365..5160607 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS24840 5157348..5158250 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMX20_RS24845 5158247..5158882 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX20_RS24850 5158879..5159808 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMX20_RS24855 5159982..5160365 - 384 WP_062921072.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX20_RS24860 5160365..5160607 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX20_RS24865 5160812..5161729 + 918 WP_065519842.1 alpha/beta hydrolase -
JMX20_RS24870 5161743..5162684 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX20_RS24875 5162729..5163166 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX20_RS24880 5163163..5164023 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMX20_RS24885 5164017..5164616 - 600 WP_114444895.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T291628 WP_062921072.1 NZ_LR890624:c5160365-5159982 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDALILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291628 WP_004150355.1 NZ_LR890624:c5160607-5160365 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References