Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2586552..2588140 Replicon chromosome
Accession NZ_LR890624
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag JMX20_RS12640 Protein ID WP_016946382.1
Coordinates 2586552..2587874 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX20_RS12645 Protein ID WP_004176198.1
Coordinates 2587874..2588140 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS12625 2581608..2584109 + 2502 WP_048289344.1 fimbrial biogenesis outer membrane usher protein -
JMX20_RS12630 2584097..2585101 + 1005 WP_009485243.1 type 1 fimbrial protein -
JMX20_RS12635 2585243..2586535 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX20_RS12640 2586552..2587874 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX20_RS12645 2587874..2588140 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX20_RS12650 2588529..2588855 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX20_RS12655 2588852..2589352 - 501 WP_032432595.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX20_RS12660 2589330..2590709 - 1380 WP_004184021.1 purine permease -
JMX20_RS12665 2591055..2592209 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX20_RS12670 2592190..2593113 - 924 WP_004184020.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T291624 WP_016946382.1 NZ_LR890624:c2587874-2586552 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291624 WP_004176198.1 NZ_LR890624:c2588140-2587874 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure

References