Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 181868..182394 Replicon plasmid 2
Accession NZ_LR890621
Organism Klebsiella pneumoniae isolate KSB2_1C-sc-2280352

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMX37_RS26785 Protein ID WP_000323025.1
Coordinates 181868..182155 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag JMX37_RS26790 Protein ID WP_004196370.1
Coordinates 182155..182394 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX37_RS26745 177183..177407 - 225 WP_014343499.1 hypothetical protein -
JMX37_RS26750 177418..177630 - 213 WP_019706020.1 hypothetical protein -
JMX37_RS26755 177691..178047 - 357 WP_019706019.1 hypothetical protein -
JMX37_RS26760 178888..179205 - 318 WP_015065519.1 hypothetical protein -
JMX37_RS26765 179220..179570 - 351 WP_032425551.1 hypothetical protein -
JMX37_RS26770 179567..179839 - 273 WP_032425552.1 hypothetical protein -
JMX37_RS26775 180537..180695 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
JMX37_RS26780 180767..181801 + 1035 Protein_193 IS481 family transposase -
JMX37_RS26785 181868..182155 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMX37_RS26790 182155..182394 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMX37_RS26795 182645..183010 + 366 WP_009651956.1 hypothetical protein -
JMX37_RS26800 183054..183791 + 738 WP_008460272.1 HupE/UreJ family protein -
JMX37_RS26805 183805..184494 + 690 WP_004196322.1 hypothetical protein -
JMX37_RS26810 184525..185901 - 1377 WP_004196363.1 chromate efflux transporter -
JMX37_RS26815 185858..186835 - 978 WP_004196334.1 chromate resistance protein -
JMX37_RS26820 186865..187057 + 193 Protein_201 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..230118 230118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291616 WP_000323025.1 NZ_LR890621:c182155-181868 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT291616 WP_004196370.1 NZ_LR890621:c182394-182155 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References