Detailed information of TA system TA291610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4868589..4870270
• Replicon: chromosome
• Accession: NZ_LR890620
• Organism: Klebsiella pneumoniae isolate KSB2_1C-sc-2280352

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: JMX37_RS23970
• Protein ID: WP_004146663.1
• Coordinates: 4868589..4869506 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JMX37_RS23975
• Protein ID: WP_101850622.1
• Coordinates: 4869512..4870270 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX37_RS23950	4863895..4865415	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
JMX37_RS23955	4865412..4866410	+	999	WP_012737175.1	ribose ABC transporter permease	-
JMX37_RS23960	4866441..4867382	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMX37_RS23965	4867457..4868464	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
JMX37_RS23970	4868589..4869506	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMX37_RS23975	4869512..4870270	-	759	WP_101850622.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMX37_RS23980	4870356..4871084	-	729	WP_004177810.1	response regulator transcription factor	-
JMX37_RS23985	4871357..4873504	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMX37_RS23990	4873734..4874420	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T291610 WP_004146663.1 NZ_LR890620:c4869506-4868589 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28579.01 Da
• Isoelectric Point: 10.0870

>AT291610 WP_101850622.1 NZ_LR890620:c4870270-4869512 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVMLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1