Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2565341..2566929 Replicon chromosome
Accession NZ_LR890620
Organism Klebsiella pneumoniae isolate KSB2_1C-sc-2280352

Toxin (Protein)


Gene name hipA Uniprot ID A0A485W5A2
Locus tag JMX37_RS12605 Protein ID WP_023342812.1
Coordinates 2565341..2566663 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX37_RS12610 Protein ID WP_024622638.1
Coordinates 2566663..2566929 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX37_RS12590 2560397..2562898 + 2502 WP_193490965.1 fimbrial biogenesis outer membrane usher protein -
JMX37_RS12595 2562886..2563890 + 1005 WP_004224758.1 type 1 fimbrial protein -
JMX37_RS12600 2564032..2565324 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX37_RS12605 2565341..2566663 - 1323 WP_023342812.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX37_RS12610 2566663..2566929 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX37_RS12615 2567194..2567520 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMX37_RS12620 2567517..2568017 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX37_RS12625 2567995..2569374 - 1380 WP_193490963.1 purine permease -
JMX37_RS12630 2569720..2570874 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX37_RS12635 2570855..2571778 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2367697..2600587 232890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5358

>T291606 WP_023342812.1 NZ_LR890620:c2566663-2565341 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT291606 WP_024622638.1 NZ_LR890620:c2566929-2566663 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A485W5A2

Antitoxin

Source ID Structure

References