Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4401568..4402826 Replicon chromosome
Accession NZ_LR890619
Organism Pseudomonas aeruginosa isolate MINF_7A-sc-2280434

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JMW66_RS20305 Protein ID WP_023084953.1
Coordinates 4401568..4402323 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag JMW66_RS20310 Protein ID WP_003086329.1
Coordinates 4402458..4402826 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW66_RS20295 4396741..4399284 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
JMW66_RS20300 4399439..4400800 - 1362 WP_003081943.1 DNA recombination protein RmuC -
JMW66_RS20305 4401568..4402323 - 756 WP_023084953.1 RES family NAD+ phosphorylase Toxin
JMW66_RS20310 4402458..4402826 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
JMW66_RS20315 4402899..4404184 - 1286 Protein_4022 FAD-binding oxidoreductase -
JMW66_RS20320 4404240..4405831 - 1592 Protein_4023 aldehyde dehydrogenase family protein -
JMW66_RS20325 4405910..4406386 + 477 WP_003140638.1 hypothetical protein -
JMW66_RS20330 4406389..4406664 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.49 Da        Isoelectric Point: 7.7294

>T291597 WP_023084953.1 NZ_LR890619:c4402323-4401568 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT291597 WP_003086329.1 NZ_LR890619:c4402826-4402458 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References