Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3448467..3449688 Replicon chromosome
Accession NZ_LR890619
Organism Pseudomonas aeruginosa isolate MINF_7A-sc-2280434

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW66_RS15835 Protein ID WP_023518577.1
Coordinates 3449110..3449688 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMW66_RS15830 Protein ID WP_003088112.1
Coordinates 3448467..3449021 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW66_RS15805 3444035..3444586 + 552 WP_003102727.1 XRE family transcriptional regulator -
JMW66_RS15810 3444583..3444981 - 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
JMW66_RS15815 3444994..3445317 - 324 WP_003102734.1 multidrug efflux SMR transporter -
JMW66_RS15820 3445648..3446109 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
JMW66_RS15825 3446114..3448309 + 2196 WP_058172530.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
JMW66_RS15830 3448467..3449021 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
JMW66_RS15835 3449110..3449688 + 579 WP_023518577.1 HD domain-containing protein Toxin
JMW66_RS15840 3449797..3450984 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
JMW66_RS15845 3450974..3453145 - 2172 WP_033980119.1 type I secretion system permease/ATPase -
JMW66_RS15850 3453135..3454412 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21815.66 Da        Isoelectric Point: 5.3577

>T291596 WP_023518577.1 NZ_LR890619:3449110-3449688 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLNY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT291596 WP_003088112.1 NZ_LR890619:3448467-3449021 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References