Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1815696..1817204 Replicon chromosome
Accession NZ_LR890619
Organism Pseudomonas aeruginosa isolate MINF_7A-sc-2280434

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag JMW66_RS08405 Protein ID WP_003119682.1
Coordinates 1815696..1816283 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JMW66_RS08410 Protein ID WP_201522627.1
Coordinates 1816350..1817204 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW66_RS08400 1811951..1815430 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
JMW66_RS08405 1815696..1816283 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
JMW66_RS08410 1816350..1817204 + 855 WP_201522627.1 AraC family transcriptional regulator Antitoxin
JMW66_RS08415 1817301..1819466 + 2166 WP_096264430.1 TonB-dependent receptor family protein -
JMW66_RS08420 1819641..1821512 + 1872 WP_201522628.1 MFS transporter -
JMW66_RS08425 1821573..1821782 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T291595 WP_003119682.1 NZ_LR890619:1815696-1816283 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31865.17 Da        Isoelectric Point: 7.5295

>AT291595 WP_201522627.1 NZ_LR890619:1816350-1817204 [Pseudomonas aeruginosa]
VPDETGGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References