291593

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 44170..44813 Replicon plasmid 3
Accession NZ_LR890618
Organism Klebsiella pneumoniae isolate INF359-sc-2280194

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMX12_RS27640 Protein ID WP_048335684.1
Coordinates 44170..44586 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag JMX12_RS27645 Protein ID WP_001261276.1
Coordinates 44583..44813 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX12_RS27625 39665..40359 + 695 WP_096807533.1 IS1 family transposase -
JMX12_RS27630 40414..43311 - 2898 WP_023307208.1 Tn3-like element Tn5403 family transposase -
JMX12_RS27635 43406..44011 + 606 WP_000509966.1 recombinase family protein -
JMX12_RS27640 44170..44586 - 417 WP_048335684.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX12_RS27645 44583..44813 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX12_RS27650 45431..45730 + 300 WP_052433691.1 hypothetical protein -
JMX12_RS27655 45785..46471 + 687 WP_114466423.1 hypothetical protein -
JMX12_RS27660 46483..47265 + 783 WP_020277927.1 site-specific integrase -
JMX12_RS27665 47800..48555 + 756 WP_001568031.1 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75695 75695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15079.57 Da        Isoelectric Point: 7.8644

>T291593 WP_048335684.1 NZ_LR890618:c44586-44170 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT291593 WP_001261276.1 NZ_LR890618:c44813-44583 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References