291588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4630908..4631718 Replicon chromosome
Accession NZ_LR890616
Organism Klebsiella pneumoniae isolate INF359-sc-2280194

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag JMX12_RS22620 Protein ID WP_014908042.1
Coordinates 4630908..4631441 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag JMX12_RS22625 Protein ID WP_023343051.1
Coordinates 4631452..4631718 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX12_RS22615 4629739..4630860 + 1122 WP_012737335.1 cupin domain-containing protein -
JMX12_RS22620 4630908..4631441 - 534 WP_014908042.1 GNAT family N-acetyltransferase Toxin
JMX12_RS22625 4631452..4631718 - 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
JMX12_RS22630 4631821..4633254 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX12_RS22635 4633244..4633927 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX12_RS22640 4634100..4635485 + 1386 WP_024623207.1 efflux transporter outer membrane subunit -
JMX12_RS22645 4635503..4635847 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T291588 WP_014908042.1 NZ_LR890616:c4631441-4630908 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT291588 WP_023343051.1 NZ_LR890616:c4631718-4631452 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References