291587

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4202945..4203651 Replicon chromosome
Accession NZ_LR890616
Organism Klebsiella pneumoniae isolate INF359-sc-2280194

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMX12_RS20610 Protein ID WP_024622903.1
Coordinates 4203283..4203651 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A485WAM6
Locus tag JMX12_RS20605 Protein ID WP_023302278.1
Coordinates 4202945..4203262 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX12_RS20560 4198086..4198910 + 825 WP_023302271.1 DUF945 domain-containing protein -
JMX12_RS20565 4199119..4199829 + 711 WP_023302272.1 DeoR family transcriptional regulator -
JMX12_RS20570 4199855..4200391 + 537 WP_023302273.1 DUF4339 domain-containing protein -
JMX12_RS20575 4200433..4200870 + 438 WP_023301392.1 hypothetical protein -
JMX12_RS20580 4200937..4201347 + 411 WP_023302274.1 hypothetical protein -
JMX12_RS20585 4201425..4201661 + 237 WP_032410024.1 DUF905 domain-containing protein -
JMX12_RS20590 4201748..4202206 + 459 WP_023302275.1 antirestriction protein -
JMX12_RS20595 4202215..4202697 + 483 WP_023302276.1 RadC family protein -
JMX12_RS20600 4202706..4202927 + 222 WP_023302277.1 DUF987 domain-containing protein -
JMX12_RS20605 4202945..4203262 + 318 WP_023302278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMX12_RS20610 4203283..4203651 + 369 WP_024622903.1 TA system toxin CbtA family protein Toxin
JMX12_RS20615 4203648..4203989 + 342 WP_024622904.1 hypothetical protein -
JMX12_RS20620 4204112..4206757 - 2646 WP_024622905.1 LuxR family transcriptional regulator -
JMX12_RS20625 4207131..4208090 + 960 WP_023302280.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13651.82 Da        Isoelectric Point: 7.2897

>T291587 WP_024622903.1 NZ_LR890616:4203283-4203651 [Klebsiella pneumoniae]
MKNLPATISQAAKPCLSPVAVWQMLLTHLLEQHYGLMLSDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRYSYREVSNIVLSRSRI

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11860.67 Da        Isoelectric Point: 6.4629

>AT291587 WP_023302278.1 NZ_LR890616:4202945-4203262 [Klebsiella pneumoniae]
MSNPTWGLLRDITPCLGARLVQEGNRLYYLVDRASITGKFSDAEILKLDVVFPHFISQMESMLTIGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYLTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A485WAM6

References