Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2669167..2670755 Replicon chromosome
Accession NZ_LR890616
Organism Klebsiella pneumoniae isolate INF359-sc-2280194

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JMX12_RS13040 Protein ID WP_023301940.1
Coordinates 2669167..2670489 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX12_RS13045 Protein ID WP_024622638.1
Coordinates 2670489..2670755 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX12_RS13025 2664223..2666724 + 2502 WP_023301938.1 fimbrial biogenesis outer membrane usher protein -
JMX12_RS13030 2666712..2667716 + 1005 WP_023301939.1 type 1 fimbrial protein -
JMX12_RS13035 2667858..2669150 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX12_RS13040 2669167..2670489 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX12_RS13045 2670489..2670755 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX12_RS13050 2671020..2671346 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMX12_RS13055 2671343..2671843 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX12_RS13060 2671821..2673200 - 1380 WP_065876454.1 purine permease -
JMX12_RS13065 2673546..2674700 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX12_RS13070 2674681..2675604 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T291585 WP_023301940.1 NZ_LR890616:c2670489-2669167 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT291585 WP_024622638.1 NZ_LR890616:c2670755-2670489 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure

References