Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824084..824741 Replicon chromosome
Accession NZ_LR890616
Organism Klebsiella pneumoniae isolate INF359-sc-2280194

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMX12_RS04145 Protein ID WP_002916310.1
Coordinates 824331..824741 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMX12_RS04140 Protein ID WP_002916312.1
Coordinates 824084..824350 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX12_RS04115 819240..820673 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMX12_RS04120 820792..821520 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMX12_RS04125 821570..821881 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMX12_RS04130 822045..822704 + 660 WP_002916317.1 hemolysin III family protein -
JMX12_RS04135 822855..823838 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
JMX12_RS04140 824084..824350 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMX12_RS04145 824331..824741 + 411 WP_002916310.1 protein YgfX Toxin
JMX12_RS04150 824748..825269 - 522 WP_004144730.1 flavodoxin FldB -
JMX12_RS04155 825370..826266 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMX12_RS04160 826289..827002 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMX12_RS04165 827008..828741 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291580 WP_002916310.1 NZ_LR890616:824331-824741 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T291580 NZ_LR890616:824331-824741 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291580 WP_002916312.1 NZ_LR890616:824084-824350 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT291580 NZ_LR890616:824084-824350 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References