Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1778..2337 Replicon plasmid 4
Accession NZ_LR890609
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag JMW69_RS24685 Protein ID WP_000421257.1
Coordinates 2062..2337 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag JMW69_RS24680 Protein ID WP_001178087.1
Coordinates 1778..2062 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS24675 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
JMW69_RS24680 1778..2062 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW69_RS24685 2062..2337 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW69_RS24690 2502..2783 + 282 WP_001105066.1 hypothetical protein -
JMW69_RS24695 2974..3240 - 267 WP_000627831.1 hypothetical protein -
JMW69_RS24700 3378..3980 - 603 WP_000521606.1 hypothetical protein -
JMW69_RS24705 4156..5208 - 1053 WP_000655519.1 hypothetical protein -
JMW69_RS24710 5421..6011 - 591 WP_001401589.1 hypothetical protein -
JMW69_RS24715 6011..6265 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..89833 89833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T291576 WP_000421257.1 NZ_LR890609:2062-2337 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT291576 WP_001178087.1 NZ_LR890609:1778-2062 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References