Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 30785..31583 Replicon plasmid 3
Accession NZ_LR890608
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JMW69_RS24200 Protein ID WP_023908317.1
Coordinates 31062..31583 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag JMW69_RS24195 Protein ID WP_001351987.1
Coordinates 30785..31054 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS24170 25906..27246 - 1341 WP_000137333.1 AAA family ATPase -
JMW69_RS24175 27290..28030 - 741 WP_001717320.1 hypothetical protein -
JMW69_RS24180 28320..29378 + 1059 WP_113519370.1 hypothetical protein -
JMW69_RS24185 29439..29792 - 354 WP_160378290.1 hypothetical protein -
JMW69_RS24190 29798..30466 - 669 WP_000161228.1 AAA family ATPase -
JMW69_RS24195 30785..31054 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
JMW69_RS24200 31062..31583 + 522 WP_023908317.1 GNAT family N-acetyltransferase Toxin
JMW69_RS24205 31751..32002 - 252 WP_001404395.1 hypothetical protein -
JMW69_RS24210 32004..32696 - 693 WP_000856757.1 hypothetical protein -
JMW69_RS24215 32710..33033 - 324 WP_001717323.1 hypothetical protein -
JMW69_RS24220 33356..33964 - 609 WP_031323050.1 hypothetical protein -
JMW69_RS24225 33964..34218 - 255 WP_000120169.1 hypothetical protein -
JMW69_RS24230 34381..34908 - 528 WP_023908314.1 tail fiber assembly protein -
JMW69_RS24235 34911..35825 - 915 WP_113519376.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 - 1..115278 115278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19497.36 Da        Isoelectric Point: 8.9815

>T291575 WP_023908317.1 NZ_LR890608:31062-31583 [Escherichia coli]
VDNIKIEIFSGEKHYDLNGFDCGEESLNAFLTNHLKRQHEGKILRAYVLCTKEGRPKVLGYYTLSGSCFEKESLPSRSQQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLDFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT291575 WP_001351987.1 NZ_LR890608:30785-31054 [Escherichia coli]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References