Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4276647..4277242 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag JMW69_RS20635 Protein ID WP_000239581.1
Coordinates 4276647..4276997 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JMW69_RS20640 Protein ID WP_001223213.1
Coordinates 4276991..4277242 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS20615 4272094..4273116 - 1023 WP_001586590.1 ABC transporter permease -
JMW69_RS20620 4273130..4274632 - 1503 Protein_4033 sugar ABC transporter ATP-binding protein -
JMW69_RS20625 4274772..4275728 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMW69_RS20630 4276038..4276568 + 531 WP_000055075.1 inorganic diphosphatase -
JMW69_RS20635 4276647..4276997 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
JMW69_RS20640 4276991..4277242 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMW69_RS20645 4277454..4277795 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMW69_RS20650 4277798..4281577 - 3780 WP_021564810.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T291563 WP_000239581.1 NZ_LR890606:c4276997-4276647 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT291563 WP_001223213.1 NZ_LR890606:c4277242-4276991 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References