Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2491869..2492507 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMW69_RS11920 Protein ID WP_000813794.1
Coordinates 2492331..2492507 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW69_RS11915 Protein ID WP_001270286.1
Coordinates 2491869..2492285 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS11895 2487021..2487962 - 942 WP_001251304.1 ABC transporter permease -
JMW69_RS11900 2487963..2488976 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JMW69_RS11905 2488994..2490139 - 1146 WP_069905164.1 ABC transporter substrate-binding protein -
JMW69_RS11910 2490384..2491790 - 1407 WP_069905165.1 PLP-dependent aminotransferase family protein -
JMW69_RS11915 2491869..2492285 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW69_RS11920 2492331..2492507 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW69_RS11925 2492729..2492959 + 231 WP_000494244.1 YncJ family protein -
JMW69_RS11930 2493051..2495012 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW69_RS11935 2495085..2495621 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JMW69_RS11940 2495674..2496888 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T291557 WP_000813794.1 NZ_LR890606:c2492507-2492331 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT291557 WP_001270286.1 NZ_LR890606:c2492285-2491869 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References