Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2347362..2347888 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMW69_RS11210 Protein ID WP_000323025.1
Coordinates 2347601..2347888 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMW69_RS11205 Protein ID WP_000534858.1
Coordinates 2347362..2347601 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS11180 2342371..2342658 + 288 Protein_2185 hypothetical protein -
JMW69_RS11185 2343427..2344740 + 1314 WP_069905218.1 ISNCY family transposase -
JMW69_RS11190 2345190..2346398 - 1209 WP_000343717.1 IS256 family transposase -
JMW69_RS11195 2346497..2346829 - 333 WP_069905221.1 FlxA-like family protein -
JMW69_RS11200 2347032..2347337 - 306 WP_001326990.1 hypothetical protein -
JMW69_RS11205 2347362..2347601 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMW69_RS11210 2347601..2347888 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMW69_RS11215 2347960..2348115 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMW69_RS11220 2348332..2348583 + 252 WP_000980994.1 hypothetical protein -
JMW69_RS11225 2348650..2348928 + 279 WP_012304870.1 hypothetical protein -
JMW69_RS11230 2348930..2349979 + 1050 WP_001265198.1 DUF968 domain-containing protein -
JMW69_RS11235 2349993..2350745 + 753 WP_001047135.1 antitermination protein -
JMW69_RS11240 2351023..2351112 - 90 WP_120795389.1 hypothetical protein -
JMW69_RS11245 2351167..2351379 - 213 WP_000087756.1 cold shock-like protein CspF -
JMW69_RS11250 2351680..2351895 + 216 WP_000066484.1 cold shock-like protein CspB -
JMW69_RS11255 2352649..2352864 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2337545..2363953 26408
- flank IS/Tn - - 2345190..2346398 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291555 WP_000323025.1 NZ_LR890606:2347601-2347888 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT291555 WP_000534858.1 NZ_LR890606:2347362-2347601 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References