Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4810246..4810762 Replicon chromosome
Accession NZ_LR890600
Organism Klebsiella pneumoniae isolate INF122-sc-2279936

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMW81_RS23445 Protein ID WP_002886902.1
Coordinates 4810246..4810530 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW81_RS23450 Protein ID WP_002886901.1
Coordinates 4810520..4810762 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW81_RS23420 4805663..4805971 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
JMW81_RS23425 4806056..4806229 + 174 WP_032410138.1 hypothetical protein -
JMW81_RS23430 4806232..4806975 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JMW81_RS23435 4807332..4809470 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW81_RS23440 4809778..4810242 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW81_RS23445 4810246..4810530 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW81_RS23450 4810520..4810762 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW81_RS23455 4810840..4812750 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMW81_RS23460 4812773..4813927 - 1155 WP_002886900.1 lactonase family protein -
JMW81_RS23465 4813994..4814734 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T291506 WP_002886902.1 NZ_LR890600:c4810530-4810246 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291506 WP_002886901.1 NZ_LR890600:c4810762-4810520 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References