Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736551..737308 Replicon chromosome
Accession NZ_LR890600
Organism Klebsiella pneumoniae isolate INF122-sc-2279936

Toxin (Protein)


Gene name tacT Uniprot ID A0A1D8JMF4
Locus tag JMW81_RS03645 Protein ID WP_044159004.1
Coordinates 736826..737308 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1D8JMH3
Locus tag JMW81_RS03640 Protein ID WP_007372584.1
Coordinates 736551..736835 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW81_RS03620 731943..732665 + 723 WP_013095151.1 TIGR03761 family integrating conjugative element protein -
JMW81_RS03625 732683..734695 + 2013 WP_044159002.1 DNA topoisomerase III -
JMW81_RS03630 735328..735819 + 492 WP_007372582.1 DUF3577 domain-containing protein -
JMW81_RS03635 735895..736395 + 501 WP_007372583.1 single-stranded DNA-binding protein -
JMW81_RS03640 736551..736835 + 285 WP_007372584.1 DUF1778 domain-containing protein Antitoxin
JMW81_RS03645 736826..737308 + 483 WP_044159004.1 GNAT family N-acetyltransferase Toxin
JMW81_RS03650 737541..738827 + 1287 WP_013095156.1 TcpQ domain-containing protein -
JMW81_RS03655 738829..739272 + 444 WP_007372587.1 type IV pilus biogenesis protein PilM -
JMW81_RS03660 739292..740965 + 1674 WP_013095157.1 PilN family type IVB pilus formation outer membrane protein -
JMW81_RS03665 740968..742248 + 1281 WP_176682058.1 type 4b pilus protein PilO2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 724421..829395 104974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-146)

Antitoxin

Vibrio phage ICP1, Orf50

(1-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17693.32 Da        Isoelectric Point: 6.9570

>T291497 WP_044159004.1 NZ_LR890600:736826-737308 [Klebsiella pneumoniae]
MEINVTAPALLTEEHVLHSFDCGNAVLDDWLRRRALKNQHLNASRTFVICPEGTACVVGYYSLATGSVSHVDLSRSLRQN
MPDPVPVVLLGRLAVDVSTQGNNFGKWLLNDAVMRVSNLADQVGIKAIMVHAIDERAKAFYEYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11078.63 Da        Isoelectric Point: 8.5684

>AT291497 WP_007372584.1 NZ_LR890600:736551-736835 [Klebsiella pneumoniae]
MQTPVRKSVRDKQINIRATDEERAVIDYAASLVNKNRTDFIIERAVHEAQNIILDQRVFVLDDARYQAFIRQLEAPVQNV
EGRQRLMDVKPEWK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JMF4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8JMH3

References