Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5193122..5193747 Replicon chromosome
Accession NZ_LR890595
Organism Klebsiella pneumoniae isolate INF223-sc-2280103

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW78_RS25025 Protein ID WP_062921072.1
Coordinates 5193122..5193505 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW78_RS25030 Protein ID WP_004150355.1
Coordinates 5193505..5193747 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW78_RS25010 5190488..5191390 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW78_RS25015 5191387..5192022 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW78_RS25020 5192019..5192948 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW78_RS25025 5193122..5193505 - 384 WP_062921072.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW78_RS25030 5193505..5193747 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW78_RS25035 5193952..5194869 + 918 WP_065519842.1 alpha/beta hydrolase -
JMW78_RS25040 5194883..5195824 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMW78_RS25045 5195869..5196306 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW78_RS25050 5196303..5197163 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMW78_RS25055 5197157..5197756 - 600 WP_114444895.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T291492 WP_062921072.1 NZ_LR890595:c5193505-5193122 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDALILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291492 WP_004150355.1 NZ_LR890595:c5193747-5193505 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References