Detailed information of TA system TA291491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4874380..4876061
• Replicon: chromosome
• Accession: NZ_LR890595
• Organism: Klebsiella pneumoniae isolate INF223-sc-2280103

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMW78_RS23550
• Protein ID: WP_004178299.1
• Coordinates: 4874380..4875297 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMW78_RS23555
• Protein ID: WP_004177809.1
• Coordinates: 4875303..4876061 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW78_RS23530	4869686..4871206	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
JMW78_RS23535	4871203..4872201	+	999	WP_031592479.1	ribose ABC transporter permease	-
JMW78_RS23540	4872232..4873173	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW78_RS23545	4873248..4874255	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
JMW78_RS23550	4874380..4875297	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW78_RS23555	4875303..4876061	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW78_RS23560	4876147..4876875	-	729	WP_002885152.1	response regulator transcription factor	-
JMW78_RS23565	4877148..4879295	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW78_RS23570	4879525..4880211	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T291491 WP_004178299.1 NZ_LR890595:c4875297-4874380 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT291491 WP_004177809.1 NZ_LR890595:c4876061-4875303 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05