Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2618610..2620198 Replicon chromosome
Accession NZ_LR890595
Organism Klebsiella pneumoniae isolate INF223-sc-2280103

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag JMW78_RS12820 Protein ID WP_016946382.1
Coordinates 2618610..2619932 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW78_RS12825 Protein ID WP_004176198.1
Coordinates 2619932..2620198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW78_RS12805 2613666..2616167 + 2502 WP_048289344.1 fimbrial biogenesis outer membrane usher protein -
JMW78_RS12810 2616155..2617159 + 1005 WP_009485243.1 type 1 fimbrial protein -
JMW78_RS12815 2617301..2618593 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW78_RS12820 2618610..2619932 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW78_RS12825 2619932..2620198 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW78_RS12830 2620587..2620913 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW78_RS12835 2620910..2621410 - 501 WP_032432595.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW78_RS12840 2621388..2622767 - 1380 WP_004184021.1 purine permease -
JMW78_RS12845 2623113..2624267 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW78_RS12850 2624248..2625171 - 924 WP_004184020.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T291488 WP_016946382.1 NZ_LR890595:c2619932-2618610 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291488 WP_004176198.1 NZ_LR890595:c2620198-2619932 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure

References