Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 13704..14347 Replicon plasmid 2
Accession NZ_LR890584
Organism Klebsiella pneumoniae isolate INF145-sc-2279981

Toxin (Protein)


Gene name vagD Uniprot ID A0A3A3ZBE4
Locus tag JMW91_RS25500 Protein ID WP_007374381.1
Coordinates 13931..14347 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G8LQB1
Locus tag JMW91_RS25495 Protein ID WP_007853351.1
Coordinates 13704..13934 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW91_RS25475 9350..9607 - 258 WP_023292103.1 hypothetical protein -
JMW91_RS25480 10211..11665 + 1455 WP_074180203.1 EAL domain-containing protein -
JMW91_RS25485 12199..12729 - 531 Protein_10 hypothetical protein -
JMW91_RS25490 12780..13130 - 351 WP_023292071.1 hypothetical protein -
JMW91_RS25495 13704..13934 + 231 WP_007853351.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMW91_RS25500 13931..14347 + 417 WP_007374381.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW91_RS25505 14420..15982 + 1563 WP_201510810.1 AAA family ATPase -
JMW91_RS25510 15967..16989 + 1023 WP_201510811.1 DNA helicase UvrD -
JMW91_RS25515 17198..17755 + 558 WP_007374384.1 OsmC family protein -
JMW91_RS25520 17939..18508 + 570 WP_042936984.1 TetR/AcrR family transcriptional regulator -
JMW91_RS25525 18525..18863 + 339 WP_007374386.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..126908 126908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15105.57 Da        Isoelectric Point: 7.8882

>T291479 WP_007374381.1 NZ_LR890584:13931-14347 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGATGPKAAPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.77 Da        Isoelectric Point: 4.4692

>AT291479 WP_007853351.1 NZ_LR890584:13704-13934 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A3ZBE4

Antitoxin

Source ID Structure
AlphaFold DB A0A3A3Z894

References