Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4716791..4717307 Replicon chromosome
Accession NZ_LR890583
Organism Klebsiella pneumoniae isolate INF145-sc-2279981

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag JMW91_RS22810 Protein ID WP_004894697.1
Coordinates 4716791..4717075 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW91_RS22815 Protein ID WP_002886901.1
Coordinates 4717065..4717307 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW91_RS22785 4712186..4712494 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
JMW91_RS22790 4712579..4712752 + 174 WP_002886906.1 hypothetical protein -
JMW91_RS22795 4712755..4713498 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
JMW91_RS22800 4713856..4715994 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
JMW91_RS22805 4716323..4716787 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW91_RS22810 4716791..4717075 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW91_RS22815 4717065..4717307 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW91_RS22820 4717385..4719295 - 1911 WP_201510737.1 BglG family transcription antiterminator -
JMW91_RS22825 4719318..4720472 - 1155 WP_004178372.1 lactonase family protein -
JMW91_RS22830 4720539..4721279 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T291477 WP_004894697.1 NZ_LR890583:c4717075-4716791 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291477 WP_002886901.1 NZ_LR890583:c4717307-4717065 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References