Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4650320..4651023 Replicon chromosome
Accession NZ_LR890583
Organism Klebsiella pneumoniae isolate INF145-sc-2279981

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JMW91_RS22500 Protein ID WP_040196446.1
Coordinates 4650320..4650661 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMW91_RS22505 Protein ID WP_040196448.1
Coordinates 4650682..4651023 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW91_RS22475 4646898..4648025 + 1128 WP_023325431.1 PAAR domain-containing protein -
JMW91_RS22480 4648015..4648278 + 264 WP_004192273.1 hypothetical protein -
JMW91_RS22485 4648424..4648558 + 135 Protein_4407 transposase -
JMW91_RS22490 4648571..4648681 - 111 Protein_4408 DUF4102 domain-containing protein -
JMW91_RS22495 4649055..4650062 - 1008 WP_004216518.1 restriction endonuclease -
JMW91_RS22500 4650320..4650661 - 342 WP_040196446.1 TA system toxin CbtA family protein Toxin
JMW91_RS22505 4650682..4651023 - 342 WP_040196448.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW91_RS22510 4651034..4651576 - 543 WP_004894621.1 DNA repair protein RadC -
JMW91_RS22515 4651589..4652032 - 444 WP_004894623.1 antirestriction protein -
JMW91_RS22520 4652063..4652884 - 822 WP_040196452.1 DUF945 domain-containing protein -
JMW91_RS22525 4652983..4653213 - 231 WP_014226751.1 DUF905 domain-containing protein -
JMW91_RS22530 4653285..4653734 - 450 WP_004215773.1 hypothetical protein -
JMW91_RS22535 4653731..4654183 - 453 WP_040196455.1 hypothetical protein -
JMW91_RS22540 4654220..4654789 - 570 WP_040196457.1 hypothetical protein -
JMW91_RS22545 4654789..4655493 - 705 WP_040196458.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4644106..4664762 20656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12791.74 Da        Isoelectric Point: 7.1648

>T291476 WP_040196446.1 NZ_LR890583:c4650661-4650320 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12829.33 Da        Isoelectric Point: 5.4792

>AT291476 WP_040196448.1 NZ_LR890583:c4651023-4650682 [Klebsiella pneumoniae]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYLVDRASITGDFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAIYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References