Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2648008..2649596 Replicon chromosome
Accession NZ_LR890583
Organism Klebsiella pneumoniae isolate INF145-sc-2279981

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag JMW91_RS12905 Protein ID WP_004892016.1
Coordinates 2648008..2649330 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW91_RS12910 Protein ID WP_004176198.1
Coordinates 2649330..2649596 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW91_RS12890 2643064..2645565 + 2502 WP_004892009.1 fimbrial biogenesis outer membrane usher protein -
JMW91_RS12895 2645553..2646557 + 1005 WP_004892012.1 type 1 fimbrial protein -
JMW91_RS12900 2646699..2647991 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW91_RS12905 2648008..2649330 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW91_RS12910 2649330..2649596 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW91_RS12915 2649861..2650187 - 327 WP_004892019.1 hydroxyisourate hydrolase -
JMW91_RS12920 2650184..2650684 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW91_RS12925 2650662..2652041 - 1380 WP_004176204.1 purine permease -
JMW91_RS12930 2652387..2653541 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
JMW91_RS12935 2653522..2654445 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T291472 WP_004892016.1 NZ_LR890583:c2649330-2648008 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291472 WP_004176198.1 NZ_LR890583:c2649596-2649330 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References