Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5150867..5151492 Replicon chromosome
Accession NZ_LR890571
Organism Klebsiella pneumoniae isolate INF327-sc-2280132

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMX40_RS24880 Protein ID WP_021312635.1
Coordinates 5150867..5151250 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX40_RS24885 Protein ID WP_004150355.1
Coordinates 5151250..5151492 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX40_RS24865 5148233..5149135 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMX40_RS24870 5149132..5149767 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX40_RS24875 5149764..5150693 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMX40_RS24880 5150867..5151250 - 384 WP_021312635.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX40_RS24885 5151250..5151492 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX40_RS24890 5151697..5152614 + 918 WP_004178029.1 alpha/beta hydrolase -
JMX40_RS24895 5152628..5153569 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX40_RS24900 5153614..5154051 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX40_RS24905 5154048..5154908 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMX40_RS24910 5154902..5155501 - 600 WP_040148118.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14349.56 Da        Isoelectric Point: 7.3178

>T291461 WP_021312635.1 NZ_LR890571:c5151250-5150867 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVATPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291461 WP_004150355.1 NZ_LR890571:c5151492-5151250 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References