Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4570361..4571171 Replicon chromosome
Accession NZ_LR890571
Organism Klebsiella pneumoniae isolate INF327-sc-2280132

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag JMX40_RS22170 Protein ID WP_040148415.1
Coordinates 4570361..4570894 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX40_RS22175 Protein ID WP_002887278.1
Coordinates 4570905..4571171 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX40_RS22165 4569192..4570313 + 1122 WP_016946712.1 cupin domain-containing protein -
JMX40_RS22170 4570361..4570894 - 534 WP_040148415.1 GNAT family N-acetyltransferase Toxin
JMX40_RS22175 4570905..4571171 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX40_RS22180 4571274..4572707 - 1434 WP_040148413.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX40_RS22185 4572697..4573380 - 684 WP_020804437.1 copper response regulator transcription factor CusR -
JMX40_RS22190 4573552..4574937 + 1386 WP_040148411.1 efflux transporter outer membrane subunit -
JMX40_RS22195 4574955..4575299 + 345 WP_040148409.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19909.78 Da        Isoelectric Point: 5.7068

>T291458 WP_040148415.1 NZ_LR890571:c4570894-4570361 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSRDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291458 WP_002887278.1 NZ_LR890571:c4571171-4570905 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References