Detailed information of TA system TA291445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4840805..4842486
• Replicon: chromosome
• Accession: NZ_LR890569
• Organism: Klebsiella pneumoniae isolate INF144-sc-2279979

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486RE08
• Locus tag: JMW96_RS23620
• Protein ID: WP_023287018.1
• Coordinates: 4840805..4841722 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486RD25
• Locus tag: JMW96_RS23625
• Protein ID: WP_023287017.1
• Coordinates: 4841728..4842486 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW96_RS23600	4836111..4837631	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JMW96_RS23605	4837628..4838626	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMW96_RS23610	4838657..4839598	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW96_RS23615	4839673..4840680	+	1008	WP_023287019.1	carbohydrate kinase family protein	-
JMW96_RS23620	4840805..4841722	-	918	WP_023287018.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW96_RS23625	4841728..4842486	-	759	WP_023287017.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW96_RS23630	4842572..4843300	-	729	WP_004177810.1	response regulator transcription factor	-
JMW96_RS23635	4843573..4845720	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW96_RS23640	4845950..4846636	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34587.04 Da
• Isoelectric Point: 5.7772

>T291445 WP_023287018.1 NZ_LR890569:c4841722-4840805 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28534.90 Da
• Isoelectric Point: 10.0870

>AT291445 WP_023287017.1 NZ_LR890569:c4842486-4841728 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A486RE08

Antitoxin

• AlphaFold DB: A0A486RD25