Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4677328..4677844 Replicon chromosome
Accession NZ_LR890569
Organism Klebsiella pneumoniae isolate INF144-sc-2279979

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JMW96_RS22785 Protein ID WP_004178374.1
Coordinates 4677328..4677612 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW96_RS22790 Protein ID WP_002886901.1
Coordinates 4677602..4677844 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW96_RS22760 4672724..4673032 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMW96_RS22765 4673117..4673290 + 174 WP_032414379.1 hypothetical protein -
JMW96_RS22770 4673293..4674036 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW96_RS22775 4674393..4676531 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW96_RS22780 4676860..4677324 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW96_RS22785 4677328..4677612 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW96_RS22790 4677602..4677844 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW96_RS22795 4677922..4679832 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMW96_RS22800 4679855..4681009 - 1155 WP_135722808.1 lactonase family protein -
JMW96_RS22805 4681076..4681816 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T291444 WP_004178374.1 NZ_LR890569:c4677612-4677328 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291444 WP_002886901.1 NZ_LR890569:c4677844-4677602 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References