Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777484..778141 Replicon chromosome
Accession NZ_LR890569
Organism Klebsiella pneumoniae isolate INF144-sc-2279979

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW96_RS03870 Protein ID WP_002916310.1
Coordinates 777731..778141 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW96_RS03865 Protein ID WP_002916312.1
Coordinates 777484..777750 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW96_RS03840 772692..774125 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMW96_RS03845 774244..774972 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW96_RS03850 775022..775333 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JMW96_RS03855 775497..776156 + 660 WP_002916317.1 hemolysin III family protein -
JMW96_RS03860 776255..777238 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
JMW96_RS03865 777484..777750 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW96_RS03870 777731..778141 + 411 WP_002916310.1 protein YgfX Toxin
JMW96_RS03875 778148..778669 - 522 WP_002916308.1 flavodoxin FldB -
JMW96_RS03880 778770..779666 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW96_RS03885 779689..780402 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW96_RS03890 780408..782141 + 1734 WP_023286863.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291436 WP_002916310.1 NZ_LR890569:777731-778141 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291436 WP_002916312.1 NZ_LR890569:777484-777750 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References