Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4849404..4851085 Replicon chromosome
Accession NZ_LR890564
Organism Klebsiella pneumoniae isolate KSB2_9A-sc-2280332

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag JMW10_RS23490 Protein ID WP_023328808.1
Coordinates 4849404..4850321 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMW10_RS23495 Protein ID WP_004177809.1
Coordinates 4850327..4851085 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW10_RS23470 4844785..4846305 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
JMW10_RS23475 4846302..4847300 + 999 WP_031592479.1 ribose ABC transporter permease -
JMW10_RS23480 4847331..4848272 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMW10_RS23485 4848347..4849279 + 933 WP_040147145.1 carbohydrate kinase family protein -
JMW10_RS23490 4849404..4850321 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMW10_RS23495 4850327..4851085 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMW10_RS23500 4851171..4851899 - 729 WP_002885152.1 response regulator transcription factor -
JMW10_RS23505 4852172..4854319 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
JMW10_RS23510 4854549..4855235 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T291432 WP_023328808.1 NZ_LR890564:c4850321-4849404 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT291432 WP_004177809.1 NZ_LR890564:c4851085-4850327 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References