Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4587015..4587825 Replicon chromosome
Accession NZ_LR890564
Organism Klebsiella pneumoniae isolate KSB2_9A-sc-2280332

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag JMW10_RS22255 Protein ID WP_040148415.1
Coordinates 4587015..4587548 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMW10_RS22260 Protein ID WP_002887278.1
Coordinates 4587559..4587825 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW10_RS22250 4585846..4586967 + 1122 WP_016946712.1 cupin domain-containing protein -
JMW10_RS22255 4587015..4587548 - 534 WP_040148415.1 GNAT family N-acetyltransferase Toxin
JMW10_RS22260 4587559..4587825 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMW10_RS22265 4587928..4589361 - 1434 WP_040148413.1 Cu(+)/Ag(+) sensor histidine kinase -
JMW10_RS22270 4589351..4590034 - 684 WP_020804437.1 copper response regulator transcription factor CusR -
JMW10_RS22275 4590206..4591591 + 1386 WP_040148411.1 efflux transporter outer membrane subunit -
JMW10_RS22280 4591609..4591953 + 345 WP_040148409.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19909.78 Da        Isoelectric Point: 5.7068

>T291430 WP_040148415.1 NZ_LR890564:c4587548-4587015 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSRDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291430 WP_002887278.1 NZ_LR890564:c4587825-4587559 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References